33 pages • 1 hour read
Richard PrestonA modern alternative to SparkNotes and CliffsNotes, SuperSummary offers high-quality Study Guides with detailed chapter summaries and analysis of major themes, characters, and more.
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In the wake of the 9/11 attacks, the United States government called on prominent virology researchers, including Peter Jahrling and the seventy-three year-old D.A. Henderson. The anthrax from the letter that reached Tom Daschle was brought to USAMRIID, where Tom Geisbert determined that he was dealing with a high-quality, effectively purified sample of anthrax spores. Anthrax itself consists of cells (not simply of virus particles) and spreads by killing its hosts, seeping from their rotting bodies into the soil, and finding new hosts. Jahrling and another high-ranking official, Major General John S. Parker, are quickly alerted to Geisbert’s work. In the meantime, mail workers begin to fall ill as the direct result of passing exposure to or simply being present in the facilities that transmitted anthrax letters.
Parker reports to the U.S. Senate to discuss the severity of the threat posed by the anthrax. Jahrling, for his part, tries to explain the quality and potency of the anthrax to the CDC, but the significance of the descriptive words that he chooses (“energetic,” “professional”) is not readily apparent to his contacts. Regardless of how it is described, the anthrax was apparently created by an expert who knew the “anthrax trick” of engineering the anthrax to form clumps (or “skulls”) that would crumble in a manner meant to optimize dispersal. Jahrling and Parker were summoned to report some of their findings to the White House. Unfortunately, as Attorney General John Ashcroft pointed out during the White House meeting, communication had broken down between agencies such as the FBI and the CDC—agencies that would need to keep in closer contact going forward. Unfortunately for Jahrling, the White House summons had distracted him from family duties, such as picking up his daughter from a dance class—leaving his wife confused and irritated as well.
Preston draws on a visit he paid to William Patrick, a biowarfare specialist and a friend of Ken Alibek, one of the bioweapons researchers who defected from Russia. Together, Patrick and Alibek use household goods to show how easily bioweapons can be dispersed. Preston also reveals a further reason for the potency of the mailed anthrax: the spores were mixed with finely-ground glass that would facilitate easy movement and spreading. Already a fearsome bioweapon, the anthrax is also one with no clear and traceable source, as becomes apparent in the course of the inconclusive investigation into the “Amerithrax” case (as the anthrax incident comes to be known) waged by the FBI. Some suspicion, however, is cast on Steve Hatfill, a researcher who turns out to have falsified some of his credentials. For all these uncertainties, a few conclusions do emerge. D.A. Henderson decides it would be futile for him to promote his long-lived idea of eradicating smallpox stores, and now seeks to contribute to Jahrling’s research efforts, which are gaining momentum. In 2002, six epidemiologists also meet to discuss models related to the spread of smallpox; the National Institutes of Health arranged the meeting. Five out of the six experts were convinced that smallpox, in current times, would rank among the most devastating biological weapons possible.
Preston begins “Superpox” by noting that the true extent of the damage that would result from a smallpox outbreak is unknowable. After all, altering smallpox in order to blow through normally effective vaccines (as Ron Jackson and the other Australian researchers altered mousepox) could impart unprecedented potency to variola. In 2002, Preston paid a visit to the St. Louis University School of Medicine; while there, he talked with Mark Buller, who was experimenting with modified strains of mousepox, and with Nanhai Chen, a virology expert from China. It was Chen’s job to create an altered or “recombinant” form of mousepox by inserting the IL-4 gene and then purifying the result. He was able to engineer four mousepox strains in five months. Within roughly one week of exposure, the recombinant virus decimated the exposed groups of mice.
These results were suggestive of the destructive potential of engineered smallpox, even though humanity would not be helpless against a modified form of the disease. New and recently administered antiviral drugs could, perhaps, provide effective protection. For Buller and Chen, the real threat would be the prospect of a country such as Saddam Hussein’s Iraq creating an IL-4 version of smallpox. For Preston, the ethical standards of contemporary scientists are all that can truly prevent a bioweapons catastrophe. Unlike the researchers who crafted the atom bomb, researchers involved with recombinant smallpox have not yet fully appreciated the destructive power of their creations.
As The Demon in the Freezer draws to a close, Preston reflects on the important, yet under-appreciated, legacy of Eradication, a program that prevented tens of millions of smallpox deaths but was never honored with an award, such as the Nobel Prize. He also recalls an incident that brought him into renewed contact with Jahrling, Hensley, and Mark Martinez: USAMRIID had acquired the preserved arm of a child that had died from smallpox. While inspecting the arm and its still visible smallpox pustules, Preston thought back on the fate of smallpox in the modern world. A new outbreak could race through dense twenty-first-century cities. Smallpox will continue to haunt humanity, since evil can never be eradicated from human nature.
With “The Anthrax Skulls,” Preston brings his narrative full circle, returning to the events that opened the narrative and led to the death of Robert Stevens—and to other individuals who, in some cases, had only passing contact with the anthrax. A reader can see by this point why the presence of smallpox in the anthrax would have been so devastating, and should be relieved that no smallpox was found. Preston, though, is not interested in offering easy comfort to his readership. He uses these chapters both to show how researchers such as Henderson and Jahrling reacted to a bioterror crisis—thus providing one final testament to the conscientious and essential work of these central figures of The Demon in the Freezer—and to indicate that the bioterrorism threat posed by smallpox and other diseases has by no means vanished.
One especially troubling aspect of biological weapons is how easily they can be manufactured, and manufactured at professional-grade quality. Preston, for instance, gives a sketch of how Ken Alibek’s extremely potent version of anthrax can be produced: “Two unrelated materials are mixed with pure powdered anthrax spores. If you walk into a Home Depot and look around, you may find at least one of the materials and probably both of them” (228). The materials needed to create highly destructive anthrax are not rare by any means; the expertise required is not in any clear respect hard to come by. Much like Chen’s IL-4 smallpox, potent anthrax relies on straightforward production methods and seems to be kept out of circulation, not because it is hard to create, but because a sense of social responsibility keeps the tricks behind anthrax hidden from the wrong parties.
However, another troubling aspect of this situation is that such a sense of social responsibility eventually may find its limit. As becomes clear in the last few pages of The Demon in the Freezer, Preston has no illusions about the potential for evil that resides in humanity, as we know it. In his own words, “We could eradicate smallpox from nature, but we could not uproot the virus from the human heart” (283). This statement may read as a pessimistic take on modern society, but Preston is by no means resigned to the idea of a bioweapons-based apocalypse. Even if humanity will always remain fallible or liable to destruction in some respects, it is still possible to access the knowledge, the perspective, and the moral sensibilities that will avert the worst catastrophes. To impart such strengths of understanding, after all, is part of the mission of a book such as The Demon in the Freezer.
By Richard Preston